Original Articles
22 May 2012
Vol. 2 No. 1 (2012)
https://doi.org/10.4081/ams.2012.e8

Evaluation of central nervous system depressant activity of Cleome rutidosperma

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Cleome rutidosperma, CNS, anticonvulsant, potentiation, muscle relaxant, anti-anxiety
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Authors

Anindya Bose
anindyabose_in@yahoo.com
Dr. BC Roy College of Pharmacy and Allied Health Sciences, Durgapur, India.
Anuradha Khuntia
Institute of Pharmacy and Technology, Salipur, Cuttack, Orissa, India.
Jayanta Kumar Gupta
Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
Sudam Si
School of Pharmaceutical Sciences, Institute for Technical Education and Research, Bhubaneswar, India.
The central nervous system (CNS) depressant activity of the ethanol extract (200 and 400 mg/kg) and its fractions (200 mg/kg each) of the aerial parts of Cleome rutidosperma was investigated in various models. The tested extract and its fractions showed significant (P<0.01) anxiolytic, anticonvulsant activity (in treating petit mal epilepsy) without any unwanted sedation effect. These findings justify the traditional use of this plant in CNS disorders.

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Evaluation of central nervous system depressant activity of Cleome rutidosperma. (2012). Alternative Medicine Studies, 2(1), e8. https://doi.org/10.4081/ams.2012.e8