Case Reports
13 March 2025
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Severe relapse of generalized psoriasis in a young patient with Löfgren syndrome history
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Psoriasis and sarcoidosis are two systemic inflammatory diseases characterized by elevated Th1 and Th17 lymphocyte activity and overlapping genetic components. Although psoriasis often accompanies known comorbidities, the simultaneous presence of acute sarcoidosis (Löfgren syndrome) is uncommon. A 23-year-old Caucasian male patient with a history of mild psoriasis without relapse since childhood presented with generalized psoriatic plaques. In May 2020, he experienced symptoms compatible with Löfgren syndrome (LöS), which followed complete resolution after three months of systemic corticosteroid therapy. After one year of treatment with adalimumab, the Psoriasis Area and Severity Index (PASI) decreased from 25.3 to 4.2, while sarcoidosis remained stable. The common pathogenic mechanisms between psoriasis and sarcoidosis warrant further investigation. This case emphasizes the importance of vigilance for respiratory symptoms in psoriasis patients and the potential for psoriasis reoccurrence post-sarcoidosis. Dermatologists need to be aware of these associations, promoting comprehensive management strategies for psoriatic patients with a history of sarcoidosis.
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Khalid U, Gislason GH, Hansen PR. Sarcoidosis in patients with psoriasis: a population-
based cohort study. PLoS One 2014;9:e109632. DOI: https://doi.org/10.1371/journal.pone.0109632
Rossides M, Darlington P, Kullberg S, Arkema EV. Sarcoidosis: Epidemiology and clinical insights. J Intern Med 2023;293:668-80. DOI: https://doi.org/10.1111/joim.13629
Grunewald J, Brynedal B, Darlington P, et al. Different HLA-DRB1 allele distributions in distinct clinical subgroups of sarcoidosis patients. Respir Res 2010;11:25. DOI: https://doi.org/10.1186/1465-9921-11-25
Ohno S, Ishigatsubo Y. The incidence of Lofgren's syndrome in Japanese: the number of patients affected, number of patients diagnosed and number of cases reported. Intern Med 2006;45:745-6. DOI: https://doi.org/10.2169/internalmedicine.45.0150
Rubio-Rivas M, Franco J, Corbella X. Sarcoidosis presenting with and without Löfgren's syndrome: Clinical, radiological and behavioral differences observed in a group of 691patients. Joint Bone Spine 2020;87:141-7. DOI: https://doi.org/10.1016/j.jbspin.2019.10.001
Sève P, Pacheco Y, Durupt F, et al. Sarcoidosis: A Clinical Overview from Symptoms to Diagnosis. Cells 2021;10:766. DOI: https://doi.org/10.3390/cells10040766
Nikolopoulou M, Katsenos S, Psathakis K, et al. Pulmonary sarcoidosis associated with psoriasis vulgaris: coincidental occurrence or causal association? Case report. BMC Pulm Med 2006;6:26. DOI: https://doi.org/10.1186/1471-2466-6-26
Strauss H. Zur Lehre von der neurogenen und der thyreogenen Glykosurie. Dtsch Med Wochenschr 1897;20:309-12. DOI: https://doi.org/10.1055/s-0029-1204995
Takeshita J, Grewal S, Langan SM, et al. Psoriasis and comorbid diseases: Epidemiology. J Am Acad Dermatol 2017;76:377-90. DOI: https://doi.org/10.1016/j.jaad.2016.07.064
Murphy MJ, Leasure AC, Damsky W, Cohen JM. Association of sarcoidosis with psoriasis: a cross-sectional study in the All of Us research program. Arch Dermatol Res 2023;315:1439-41. DOI: https://doi.org/10.1007/s00403-022-02488-z
Buja A, Miatton A, Cozzolino C, et al. The Prevalent Comorbidome at the Onset of Psoriasis Diagnosis. Dermatol Ther (Heidelb) 2023;13:2093-105. DOI: https://doi.org/10.1007/s13555-023-00986-0
Petroianni A, Halili I, Lagalla M, et al. Sarcoidosis at onset of Psoriasis: a common immunopathogenesis. Review and case report. Eur Rev Med Pharmacol Sci 2015;19:1773-8.
Kim YS, Choi JE, Han TY, et al. Simultaneous Improvement of Cutaneous Sarcoidosis and Psoriasis Vulgaris on Administration of a Tumor Necrosis Factor Alpha Inhibitor. Ann Dermatol. 2023 May;35(Suppl 1):S158-60. DOI: https://doi.org/10.5021/ad.21.081
Sahraoui H, Ait Malek S, Kherrab A, et al. Association of sarcoidosis and psoriasis: A
difficult diagnosis. Int. J. Clin. Rheumatol 2017;12:97. DOI: https://doi.org/10.4103/injr.injr_96_16
Huang MY, Armstrong AW. Janus-kinase inhibitors in dermatology: A review of their use in psoriasis, vitiligo, systemic lupus erythematosus, hidradenitis suppurativa, dermatomyositis, lichen planus, lichen planopilaris, sarcoidosis and graft-versus-host disease. Indian J Dermatol Venereol Leprol 2023;90:30-40. DOI: https://doi.org/10.25259/IJDVL_15_2023
Sweiss NJ, Noth I, Mirsaeidi M, et al. Efficacy Results of a 52-week Trial of Adalimumab in the Treatment of Refractory Sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2014;31:46-54.
Daïen CI, Monnier A, Claudepierre P, et al. Sarcoid-like granulomatosis in patients treated with tumor necrosis factor blockers: 10 cases. Rheumatology (Oxford). 2009;48:883-6. DOI: https://doi.org/10.1093/rheumatology/kep046
Mazur M, Twardowska A, Czerw A, et al. Acute sarcoidosis (Löfgren's syndrome) in a patient treated with etanercept for psoriatic arthritis—case report and impacts of biologic agents review. J Clin Exp Dermatol Res 2017;8:1-4. DOI: https://doi.org/10.4172/2155-9554.1000435
Narcisi A, Valenti M, De Simone C, et al. Effects of TNF-α inhibition on pre-clinical enthesitis: observational study on 49 psoriatic patients. J Dermatolog Treat 2022;33:1703-6. DOI: https://doi.org/10.1080/09546634.2021.1899112
Gisondi P, Tinazzi I, El-Dalati G, et al. Lower limb enthesopathy in patients with psoriasis without clinical signs of arthropathy: a hospital-based case-control study. Ann Rheum Dis 2008;67:26-30. DOI: https://doi.org/10.1136/ard.2007.075101
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Severe relapse of generalized psoriasis in a young patient with Löfgren syndrome history. (2025). Dermatology Reports. https://doi.org/10.4081/dr.2025.10021
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