Case Reports
9 May 2025

Unusual presentation of skin nodule in a child: a case report of primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder and literature review

Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
140
Views
57
Downloads

Authors

Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder (SMPLPD) is a rare, definite type of cutaneous T-cell lymphoma (CTCL) that accounts for 6% of all primary CTCLs. Characteristically, this lymphoproliferative disorder presents as a solitary nodule, plaque, or tumor, generally on the face, neck, or upper trunk. We report a case of SMPLPD presenting as a facial nodule in a 6-year-old Saudi girl. The patient was successfully treated with complete excision and showed full resolution, with no recurrence at 6-month follow-up.

Altmetrics

Downloads

Download data is not yet available.

Citations

Willemze R. Cutaneous T-cell lymphoma. In: Bolognia J, Schaffer J, Cerroni L, eds. Dermatology. 4th ed. China: Elsevier, 2018, pp. 2127-47.
Melchers S, Albrecht J, Kempf W, Nicolay J. The fifth edition of the WHO classification—what is new for cutaneous lymphomas? J Dtsch Dermatol Ges 2024;22:1254-65. DOI: https://doi.org/10.1111/ddg.15361
Concilla A, Militello M, Ferrer-Bruker S. A case of primary cutaneous CD4+ small/medium sized pleomorphic T-cell lymphoproliferative disorder. South Atlantic Division GME Research Day 2024;89 [cited 2024 Jun. 27]. Available from: https://scholarlycommons.hcahealthcare.com/southatlantic2024/89/
Zengarini C, Guglielmo A, Mussi M, et al. Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder nodule successfully treated with laser CO2 ablation: a case report and literature review. Dermatol Reports [Internet] 2024 [cited 2024 Feb. 6]. Available from: https://www.pagepress.org/journals/dr/article/view/9884 DOI: https://doi.org/10.4081/dr.2024.9884
Kazan D, Bayramgürler D, Tuğrul EA, Demirkesen C. An atypical presentation of primary cutaneous CD4+ small/medium pleomorphic T-cell lymphoproliferative disorder. Dermatol Pract Concept 2023;13:e2023221. DOI: https://doi.org/10.5826/dpc.1304a221
Kim J, Jeong M, Jun D, et al. Primary cutaneous CD4+ small/medium T-cell lymphoma: a case report. Arch Craniofac Surg 2021;22:199-203. DOI: https://doi.org/10.7181/acfs.2021.00199
Valentim FDO, Oliveira CC, Miot HA. Case for diagnosis. Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder. An Bras Dermatol 2019;94:99-101. DOI: https://doi.org/10.1590/abd1806-4841.20198513
Jain G, Aiyer HM. Primary cutaneous CD4 positive small/medium T cell lymphoma. Indian J Dermatol Venereol Leprol‏ 2018;84:186-8. DOI: https://doi.org/10.4103/ijdvl.IJDVL_91_17
Koper M, Putała-Pośpiech M, Biernat W, et al. Primary cutaneous CD4+ small-/medium-sized T-cell lymphoproliferative disorder: a case report. Clin Case Rep 2019;7:703-06. DOI: https://doi.org/10.1002/ccr3.2018
Keeling BH, Gavino AC, Admirand J, Soldano AC. Primary cutaneous CD4-positive small/medium-sized pleomorphic T-cell lymphoproliferative disorder: report of a case and review of the literature. J Cutan Pathol 2017;44:944-7.‏ DOI: https://doi.org/10.1111/cup.13011
Micković M, Dinić M, Tirnanić T, et al. Primary cutaneous CD4-positive small/medium pleomorphic T-cell lymphoma—a case report. Serb J Dermatol Venerol 2016;8:221-6.‏
Topal IO, Goncu EK, Ozekinci S, et al. Primary cutaneous CD4 (+) small/medium‐sized T‐cell lymphoma of the face: successful treatment with radiation therapy. J Dtsch Dermatol Ges 2016;14:522-4. DOI: https://doi.org/10.1111/ddg.12878
Li D, Guo B, Li D, et al. Primary cutaneous CD4+ small-to-medium-sized pleomorphic T-cell lymphoma: a rare case report of infant. J Clin Pathol 2015;68:855-8.‏ DOI: https://doi.org/10.1136/jclinpath-2015-203113
Volks N, Oschlies I, Cario G, et al. Primary cutaneous CD4+ small to medium‐size pleomorphic T‐cell lymphoma in a 12‐year‐old girl. Pediatr Dermatol 2013;30:595-9. DOI: https://doi.org/10.1111/pde.12168
Zhang L, Shao H. Primary cutaneous CD4 positive small/medium T-cell lymphoma with high proliferation index and CD30-positive large lymphoid cells. J Cutan Pathol 2013;40:720-24. DOI: https://doi.org/10.1111/cup.12169
Toberer F, Hartschuh W, Hadaschik E. Primary cutaneous CD4+ small-to medium-sized pleomorphic T-cell lymphoma: temporary remission by oral doxycycline. JAMA Dermatol 2013;149:956-9.‏ DOI: https://doi.org/10.1001/jamadermatol.2013.4162
Choi M, Park SY, Park HS, et al. A case of primary cutaneous CD4 positive small/medium T cell lymphoma. Ann Dermatol 2011;23:76-80.‏ DOI: https://doi.org/10.5021/ad.2011.23.1.76
Alberti-Violetti S, Torres-Cabala CA, Talpur R, et al. Clinicopathological and molecular study of primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma. J Cutan Pathol 2016;43:1121-30. DOI: https://doi.org/10.1111/cup.12806
Surmanowicz P, Doherty S, Sivanand A, et al. The clinical spectrum of primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoproliferative disorder: an updated systematic literature review and case series. Dermatology 2021;237:618-28. DOI: https://doi.org/10.1159/000511473

How to Cite



Unusual presentation of skin nodule in a child: a case report of primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder and literature review. (2025). Dermatology Reports. https://doi.org/10.4081/dr.2025.10163