Letters
28 February 2025
Early Access
Novel therapeutic approach for loxoscelism: efficacy of cefixime and netilmicin sulfate combination therapy
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
158
Views
144
Downloads
Authors
Dear Editor,
Loxoscelism, caused by bites from Loxosceles spiders, notably Loxosceles reclusa, presents with necrotic skin lesions and, in severe cases, systemic symptoms such as hemolysis, acute renal failure, and disseminated intravascular coagulation (DIC). The venom’s sphingomyelinase D (SMD) enzyme induces direct tissue damage and an inflammatory response, leading to cell death, dermal necrosis, and increased vascular permeability, which can result in hemolysis and thrombosis. [...]
Altmetrics
Downloads
Download data is not yet available.
Citations
Gremski LH, da Justa HC, Polli NLC, et al. Systemic Loxoscelism, Less Frequent but More Deadly: The Involvement of Phospholipases D in the Pathophysiology of Envenomation. Toxins (Basel) 2022;15:17. DOI: https://doi.org/10.3390/toxins15010017
Monteiro CL, Rubel R, Cogo LL, et al. Isolation and identification of Clostridium perfringens in the venom and fangs of Loxosceles intermedia (brown spider): enhancement of the dermonecrotic lesion in loxoscelism. Toxicon 2002;40:409-18. DOI: https://doi.org/10.1016/S0041-0101(01)00209-4
Fagan SP, Berger DH, Rahwan K, Awad SS. Spider Bites Presenting with Methicillin-Resistant Staphylococcus aureus Soft Tissue Infection Require Early Aggressive Treatment. Surg Infect (Larchmt) 2003;4:311-5. DOI: https://doi.org/10.1089/109629603322761364
Caporossi A, Alessio G, Fasce F, et al. Short-Term Use of Dexamethasone/Netilmicin Fixed Combination in Controlling Ocular Inflammation After Uncomplicated Cataract Surgery. Clin Ophthalmol 2021;15:2847-54. DOI: https://doi.org/10.2147/OPTH.S311846
Arumugham VB, Gujarathi R, Cascella M. Third-Generation Cephalosporins. 2023 Jun 4. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024.
How to Cite
Novel therapeutic approach for loxoscelism: efficacy of cefixime and netilmicin sulfate combination therapy. (2025). Dermatology Reports. https://doi.org/10.4081/dr.2025.10215
Copyright (c) 2025 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
