Letters
11 July 2025
Early Access
https://doi.org/10.4081/dr.2025.10237

Primary cutaneous marginal zone lymphoma in a patient with multiple sclerosis under fingolimod therapy

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lymphoma, B cell lymphoma, fingolimod, sphingosine-1-phosphate receptor antagonist, T cell lymphoma
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Authors

Thilo Gambichler
gambichler@me.com
Department of Dermatology, Dortmund Hospital gGmbH, Witten-Herdecke University, Dortmund, Germany.
Sera Selina Weyer-Fahlbusch
Department of Dermatology, Dortmund Hospital gGmbH, Witten-Herdecke University, Dortmund, Germany.
Markus Werner
Department of Dermatology, Dortmund Hospital gGmbH, Witten-Herdecke University, Dortmund, Germany.
Ulrika Schade
Hematopathology Lübeck Center, Germany.
Lieselotte Bissels
Department of Neurology, Dortmund Hospital gGmbH, Witten-Herdecke University, Dortmund, Germany.
Laura Susok
Department of Dermatology, Christian Hospital, Unna, Germany.

Dear Editor,

Increased prevalence of cancer, in particular lymphomas, has been observed in patients with multiple sclerosis (MS) treated with fingolimod. We report the first case of primary cutaneous marginal zone lymphoma (PCMZL) that developed under long-term fingolimod therapy for MS. [...]

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4. Froehlich A, Schmidt S, Landsberg J, et al. Spontaneous regression of tumor-stage cutaneous T-cell lymphoma in a multiple sclerosis patient after discontinuing fingolimod. Mult Scler 2018;24:1785-7. DOI: https://doi.org/10.1177/1352458518774444
5. Soma L, Crisan L, Reid J, et al. Epstein-Barr virus-positive, primary cutaneous marginal zone lymphoma, with transformation: Case report and review of the literature. Am J Clin Pathol 2024:aqae124. DOI: https://doi.org/10.1093/ajcp/aqae124
6. Stitt DW, Boes CJ, Flanagan EP, et al. A Case of cutaneous large B-cell lymphoma during treatment of multiple sclerosis with fingolimod. Mult Scler Relat Disord 2018;19:115-7. DOI: https://doi.org/10.1016/j.msard.2017.11.014
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Thilo Gambichler, Department of Dermatology, Dortmund Hospital gGmbH, Witten-Herdecke University, Dortmund

Department of Dermatology, Christian Hospital, Unna; Department of Dermatology, Ruhr-University Bochum, Germany.

How to Cite



Primary cutaneous marginal zone lymphoma in a patient with multiple sclerosis under fingolimod therapy. (2025). Dermatology Reports. https://doi.org/10.4081/dr.2025.10237
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