Articles
2 September 2025
Early Access
https://doi.org/10.4081/dr.2025.10270

Clinical features, safety, and efficacy of combining Q-switched Nd:YAG laser and FOB® Tri-White Serum in melasma treatment

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Melasma, Q-switched Nd:YAG laser, Tri-White Serum
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Thi Xuan Tam Huynh
tamhtx@pnt.edu.vn
Pham Ngoc Thach University of Medicine, Ho Chi Minh, Viet Nam.
Bay Quach Thi
Can Tho Medical University, Can Tho, Viet Nam.

Melasma is a benign skin condition characterized by hyperpigmented patches, primarily affecting the face, and significantly reducing patients’ quality of life. Treatment is challenging due to its recurrent nature, with no single modality proving universally effective. The combination of Q-switched Nd:YAG laser treatment and FOB® Tri-White Serum (Hong Nhung Cosmetics Co., Ltd., Can Tho, Vietnam) may represent a promising new therapeutic approach. This cross-sectional descriptive study involved 85 female patients with melasma treated at two dermatological centers between July 2023 and June 2024. Patients underwent four Q-switched Nd:YAG laser sessions (1064 nm, 1.5-1.7 J/cm2) at three-week intervals and applied FOB® Tri-White Serum twice or three times daily. Treatment effectiveness was assessed using the Melasma Area Severity Index (MASI) score and the Felix Von Luschan skin color chart. Data were analyzed using Stata 17.0 MP, with p<0.05 considered statistically significant. The mean MASI score improved significantly from 7.5±4.7 to 4.9±3.5 (p<0.05), with a 69.4% response rate. Younger patients (<45 years), individuals with a shorter disease duration (≤36 months), and cases of mild to moderate melasma exhibited more favorable outcomes. Adverse effects from both the laser and serum were mild and transient. The combination of Q-switched Nd:YAG laser and FOB® Tri-White Serum is a safe and effective treatment for melasma, demonstrating significant improvement in pigmentation with minimal side effects. Further research is needed to validate these findings with larger sample sizes and control groups.

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1. Victor FC, Gelber J, Rao B. Melasma: a review. J Cutan Med Surg 2004;8:97-102. DOI: https://doi.org/10.1177/120347540400800204
2. Babbush KM, Babbush RA, Khachemoune A. The therapeutic use of antioxidants for melasma. J Drugs Dermatol 2020;19:788-92. DOI: https://doi.org/10.36849/JDD.2020.5079
3. Choi YJ, Nam JH, Kim JY, et al. Efficacy and safety of a novel picosecond laser using combination of 1 064 and 595 nm on patients with melasma: a prospective, randomized, multicenter, split‐face, 2% hydroquinone cream‐controlled clinical trial. Lasers Surg Med 2017;49:899-907. DOI: https://doi.org/10.1002/lsm.22735
4. Chandorkar N, Tambe S, Amin P, Madankar CS. Alpha Arbutin as a Skin Lightening Agent: A Review. Int J Pharm Res 2021;13. DOI: https://doi.org/10.31838/ijpr/2021.13.02.446
5. Cao T. Clinical Characteristics, Related Factors, and Evaluation of Treatment Outcomes of Freckles with Q-Switched Nd:YAG Laser Combined with Topical Tri-White Serum at Can Tho University of Medicine and Pharmacy Hospital, 2021–2022. Can Tho Journal of Medicine and Pharmacy 2023:121-9.
6. Sullivan GM, Artino Jr AR. Analyzing and interpreting data from Likert-type scales. J Grad Med Educ 2013;5:541-2. DOI: https://doi.org/10.4300/JGME-5-4-18
7. Treesirichod A, Chansakulporn S, Wattanapan P. Correlation between skin color evaluation by skin color scale chart and narrowband reflectance spectrophotometer. Indian J Dermatol 2014;59:339-42. DOI: https://doi.org/10.4103/0019-5154.135476
8. Molinar VE, Taylor SC, Pandya AG. What’s new in objective assessment and treatment of facial hyperpigmentation? Dermatol Clin 2014;32:123-35. DOI: https://doi.org/10.1016/j.det.2013.12.008
9. Abdel Hay R, Mohammed FN, Sayed KS, et al. Dermoscopy as a useful tool for evaluating melasma and assessing the response to 1064‐nm Q‐switched Nd: YAG laser. Dermatol Ther 2020;33:e13629. DOI: https://doi.org/10.1111/dth.13629
10. Gokalp H, Akkaya AD, Oram Y. Long‐term results in low‐fluence 1064‐nm Q‐Switched Nd: YAG laser for melasma: Is it effective? J Cosmet Dermatol 2016;15:420-6. DOI: https://doi.org/10.1111/jocd.12253
11. Jang HW, Chun SH, Park HC, et al. Comparative study of dual-pulsed 1064 nm Q-switched Nd: YAG laser and single-pulsed 1064 nm Q-switched Nd: YAG laser by using zebrafish model and prospective split-face analysis of facial melasma. J Cosmet Laser Ther 2017;19:114-23. DOI: https://doi.org/10.1080/14764172.2016.1262958
12. Yue B, Yang Q, Xu J, Lu Z. Efficacy and safety of fractional Q-switched 1064-nm neodymium-doped yttrium aluminum garnet laser in the treatment of melasma in Chinese patients. Lasers Med Sci 2016;31:1657-63. DOI: https://doi.org/10.1007/s10103-016-2034-4
13. Garg S, Vashisht KR, Makadia S. A prospective randomized comparative study on 60 Indian patients of melasma, comparing pixel Q-switched NdYAG (1064 nm), super skin rejuvenation (540 nm) and ablative pixel erbium YAG (2940 nm) lasers, with a review of the literature. J Cosmet Laser Ther 2019;21:297-307. DOI: https://doi.org/10.1080/14764172.2019.1605447
14. Lee YS, Lee YJ, Lee JM, et al. The low-fluence Q-switched Nd: YAG laser treatment for melasma: a systematic review. Medicina 2022;58:936. DOI: https://doi.org/10.3390/medicina58070936
15. Micek I, Pawlaczyk M, Kroma A, et al. Treatment of melasma with a low‐fluence 1064 nm Q‐switched Nd: YAG laser: Laser toning in Caucasian women. Lasers Surg Med 2022;54:366-73. DOI: https://doi.org/10.1002/lsm.23474
16. Cheng J, Vashi NA. Chemical Peels in Ethnic Skin. In: Vashi NA, Maibach HI, editors. Dermatoanthropology of Ethnic Skin and Hair. Cham: Springer; 2017:437-48. DOI: https://doi.org/10.1007/978-3-319-53961-4_24
17. Guo EL, Wang JV, Geronemus RG, Friedman PM. Combination treatment approach to melasma. Adv Cosmet Surg 2021;4:97-107. DOI: https://doi.org/10.1016/j.yacs.2021.01.013
18. Ibrahim SM, Farag AS, Ali MS, El‐Gendy WM. Efficacy and safety of topical silymarin versus low fluence 1064‐nm Q switched Nd: YAG laser in the treatment of melasma: a comparative randomized trial. Lasers Surg Med 2021;53:1341-7. DOI: https://doi.org/10.1002/lsm.23440
19. Luu TL, Huynh VB, Ngo MV, HH N. Evaluation of Treatment Outcomes of Melasma with Q-Switched Nd:YAG Laser Combined with Topical Melatonin Cream and Tri-White Serum at Can Tho University of Medicine and Pharmacy Hospital and FOB International Institute of Aesthetic Dermatology, 2022–2023. Vietnam Med J 2023;531.

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Clinical features, safety, and efficacy of combining Q-switched Nd:YAG laser and FOB® Tri-White Serum in melasma treatment. (2025). Dermatology Reports. https://doi.org/10.4081/dr.2025.10270
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