Letters to the Editor
25 September 2025
Early Access
Neurothekeoma: a pediatric case report and literature review
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Dear Editor,
Neurothekeoma is a rare, benign, soft tissue tumor that primarily affects the dermis. Initially described as a variant of nerve sheath myxoma, it was later recognized as a distinct entity because of its histopathological and immunohistochemical differences, as it is thought to be derived from fibroblast. It is most commonly observed in children and young adults, is more frequent in females, and typically arises in the head, neck, and upper extremities. [...]
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Citations
1. Sheth S, Li X, Binder S, Dry SM. Differential gene expression profiles of neurothekeomas and nerve sheath myxomas by microarray analysis. Mod Pathol 2011;24:343-54. DOI: https://doi.org/10.1038/modpathol.2010.203
2. Fetsch JF, Laskin WB, Hallman JR, et al. Neurothekeoma: an analysis of 178 tumors with detailed immunohistochemical data and long-term patient follow-up information. Am J Surg Pathol 2007;31:1103-14. DOI: https://doi.org/10.1097/PAS.0b013e31802d96af
3. Hornick JL, Fletcher CDM. Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol 2007;31:329-40. DOI: https://doi.org/10.1097/01.pas.0000213360.03133.89
4. Yun SJ, Park HS, Lee JB, et al. Myxoid Cellular Neurothekeoma: A New Entity of S100- Negative, CD68-Positive Myxoid Neurothekeoma. Ann Dermatol 2014;26:510-3. DOI: https://doi.org/10.5021/ad.2014.26.4.510
5. Stratton J, Billings SD. Cellular neurothekeoma: analysis of 37 cases emphasizing atypical histologic features. Mod Pathol 2014;27:701-10. DOI: https://doi.org/10.1038/modpathol.2013.190
6. Busam KJ, Mentzel T, Colpaert C, et al. Atypical or worrisome features in cellular neurothekeoma: a study of 10 cases. Am J Surg Pathol 1998;22:1067-72. DOI: https://doi.org/10.1097/00000478-199809000-00004
7. Plaza JA, Torres-Cabala C, Evans H, et al. Immunohistochemical expression of S100A6 in cellular neurothekeoma: clinicopathologic and immunohistochemical analysis of 31 cases. Am J Dermatopathol 2009;31:419-22. DOI: https://doi.org/10.1097/DAD.0b013e3181a13afc
8. Bortoluzzi P, Romagnuolo M, Mandolini PL, et al. Dermatoscopy of cellular neurothekeoma. JAAD Case Rep 2022;22:14-7. DOI: https://doi.org/10.1016/j.jdcr.2022.01.036
9. Choi S, Cho SI, Lee C, et al. Dermoscopy of multiple cellular neurothekeoma: An analysis of 11 neurothekeomas in a middle-aged woman. Australas J Dermatol 2020;61. DOI: https://doi.org/10.1111/ajd.13185
How to Cite
Neurothekeoma: a pediatric case report and literature review. (2025). Dermatology Reports. https://doi.org/10.4081/dr.2025.10444
Copyright (c) 2025 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
