Reviews
1 January 2022
Vol. 14 No. 2 (2022)
https://doi.org/10.4081/dr.2022.9170

Bullous pemphigoid and radiotherapy: case report and literature review update

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Bullous pemphigoid; Radiotherapy; Review; Personalized medicine
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Authors

Antonio Piras
https://orcid.org/0000-0003-2361-9327
UO Radioterapia Oncologica, Villa Santa Teresa, Bagheria, Palermo, Italy.
Bruno Fionda
https://orcid.org/0000-0003-3368-1810
UOC Radioterapia Oncologica - Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Dipartimento di Diagnostica per immagini, Radioterapia Oncologica ed Ematologia, Rome, Italy.
Antonella Sanfratello
https://orcid.org/0000-0002-6735-8029
Università degli Studi di Palermo, Radioterapia Oncologica, Palermo, Italy.
Andrea D'Aviero
andrea.daviero@guest.policlinicogemelli.it
UOC Radioterapia Oncologica - Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Dipartimento di Diagnostica per immagini, Radioterapia Oncologica ed Ematologia, Rome, Italy.
Giovanni Sortino
UO Oncologia, Fondazione Istituto G. Giglio, Cefalù, Palermo, Italy.
Gianfranco Pernice
UO Oncologia, Fondazione Istituto G. Giglio, Cefalù, Palermo, Italy.
Luca Boldrini
UOC Radioterapia Oncologica - Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Dipartimento di Diagnostica per immagini, Radioterapia Oncologica ed Ematologia, Rome; Università Cattolica del Sacro Cuore, Rome, Italy.
Tommaso Angileri
UO Radiologia, Villa Santa Teresa, Bagheria, Palermo, Italy.
Antonino Daidone
UO Radioterapia Oncologica, Villa Santa Teresa, Bagheria, Palermo, Italy.

Bullous pemphigoid (BP) is a common autoimmune bullous disease generally occurring in elderly patients. Itchy and tense blisters on normal skin or erythematous and edematous lesions on the trunk and extremities usually characterize BP. Trigger factors are still unclear while several case reports suggest a potential role of radiotherapy (RT) as BP trigger for disease onset or recrudescence. A review was performed to provide an update of literature. A case report of a patient affected by BP undergoing two radiotherapy courses for a primary breast cancer was also reported. A comprehensive review of the published literature was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The review included studies describing BP and its relationships with RT treatments. A total of 13 articles were reviewed. Studies characteristics analysis resulted in eleven case reports, one case series and one large-scale case– control study. Literature update confirms the existence of a reasonable connection between RT and BP. Case report showed that a multidisciplinary management seems to assure the feasibility of RT in patients affected by BP, not depriving them of standard therapeutic opportunities.

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How to Cite



Bullous pemphigoid and radiotherapy: case report and literature review update. (2022). Dermatology Reports, 14(2). https://doi.org/10.4081/dr.2022.9170