Case Reports
16 September 2022
Vol. 15 No. 2 (2023)
https://doi.org/10.4081/dr.2022.9569

A rare ossifying trichilemmal cyst in a young female patient: case report and literature review

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Trichilemmal cyst, ossification, surgical excision, recurrence
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Authors

Evanthia Serpetsidaki
e.serpetsidaki@gmail.com
https://orcid.org/0000-0001-8928-1029
Faculty of Medicine, National and Kapodistrian University of Athens, Greece.
Ioannis G. Gkionis
Department of General Surgery, Venizeleio General Hospital, Heraklion, Crete, Greece.
Roxani N. Arvelaki
Department of General Surgery, Venizeleio General Hospital, Heraklion, Crete, Greece.
Zafeiro I. Karafoulidou
Department of General Surgery, Venizeleio General Hospital, Heraklion, Crete, Greece.
Anastasios F. Dimou
Department of General Surgery, Venizeleio General Hospital, Heraklion, Crete, Greece.
Maria Kafousi
Laboratory of Pathology, Heraklion, Crete, Greece.

Trichilemmal cysts (TCs) constitute the second most common cutaneous cysts and are mostly presented on the scalp of middleaged women. Therefore, it is unusual for a young person to have a TC and it is extremely rare for a TC to be ossified. In the literature, only 8 cases of TCs with concomitant ossification have been described. We report the case of a 22-year-old female who presented with a scalp nodule and was treated via surgical excision of the lesion. The pathology examination of the surgical specimen revealed a lesion consisting of a multilayered squamous epithelium of slightly eosinophilic maturing keratinocytes. There was no granular layer, whereas the core of the lesion was occupied by mature bone tissue with calcium deposits. The definite diagnosis of the pathology report was ossifying TC. The aim of this report is, to enlighten clinicians about this rare pathological entity.

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Pusiol T, Morichetti D, Zorzi MG, Francesco P. Ossifying trichilemmal cyst. Am J Dermatopathol 2011;33:867-8.
Kamyab K, Kianfar N, Dasdar S, et al. Cutaneous cysts: a clinicopathologic analysis of 2,438 cases. Int J Dermatol 2020;59:457-62.
Kolodney MS, Coman GC, Smolkin MB, et al. Hereditary trichilemmal cysts are caused by two hits to the same copy of the phospholipase c delta 1 gene (PLCD1). Sci Rep 2020;10:6035.
Hörer S, Marrakchi S, Radner FP, et al. A monoallelic two-hit mechanism in PLCD1 explains the genetic pathogenesis of hereditary trichilemmal cyst formation. J Invest Dermatol 2019;139:2154-63.
Baldovini C, Rosini F, Marucci G. Osseous metaplasia and mature bone formation with extramedullary hematopoiesis in trichilemmal cyst. Am J Dermatopathol 2014;36:444-6.
Fletcher CD. Calcifying and ossifying soft tissue lesions presenting in the skin. J Cutan Pathol 1996;23:297.
Civatte J, Tsoïtis G, Le Roux P. Perforating ossified (trichilemmal) "sebaceous" cyst. Apropos of a case. Ann Dermatol Syphiligr (Paris) 1974;101:155-70.
Mommers XA, Henault B, Aubriot MH, et al. Multiple ossifying trichilemmal cysts of the scalp: a familial case. Rev Stomatol Chir Maxillofac 2012;113:53-6.
Bär M, Kayser DM, Trniková M, Grunow N. Perforating and ruptured trichilemmal cyst with metaplastic ossification. Pathologe 2012;33:459-62.
Bulut AŞ. Trichilemmal cyst with ossification and marrow formation: a case report. J Turk Acad Dermatol 2012;6:1263c4.
Abreu Velez AM, Brown VM, Howard MS. An inflamed trichilemmal (pilar) cyst: not so simple? N Am J Med Sci 2011;3:431-4.
He P, Chen W, Zhang Q, et al. Distinguishing a trichilemmal cyst from a pilomatricoma with ultrasound. J Ultrasound Med 2020;39:1939-45.
Singh P, Usman A, Motta L, Khan I. Malignant proliferating trichilemmal tumour. BMJ Case Rep 2018;2018:bcr2018224460.
Osto M, Parry N, Rehman R, et al. Malignant proliferating trichilemmal tumor of the scalp: a systematic review. Am J Dermatopathol 2021;43:851-66.
Anolik R, Firoz B, Walters RF, et al. Proliferating trichilemmal cyst with focal calcification. Dermatol Online J 2008;14:25.

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A rare ossifying trichilemmal cyst in a young female patient: case report and literature review. (2022). Dermatology Reports, 15(2). https://doi.org/10.4081/dr.2022.9569
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