Case Reports
14 March 2024
Vol. 16 No. 1 (2024)
A case of grade 3 squamous cell carcinoma successfully treated with methotrexate
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Cutaneous squamous cell carcinoma (cSCC) is a nonmelanoma skin cancer whose lesions mostly arise on lightexposed sites. Patients with compromised immunity, Fitzpatrick I or II skin phototype, and previous burn scars or radiations are more at risk of developing it. The treatment of choice for cSCC is surgery; however nonsurgical options are generally reserved for patients who refuse a very invasive treatment or cannot tolerate a surgical procedure. We report a case of cSCC successfully treated with intralesional methotrexate.
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Citations
Cazaña TG, Salazar N, Zamarrón, et al. Resistance of Nonmelanoma Skin Cancer to Nonsurgical Treatments. Part II: Photodynamic Therapy, Vismodegib, Cetuximab, Intralesional Methotrexate, and Radiotherapy. Actas Dermo- Sifiliográficas 2016;107:740-50. DOI: https://doi.org/10.1016/j.adengl.2016.08.017
Vega-González LG, Morales-Pérez MI, Molina-Pérez T, Sereno-Gómez B. Successful treatment of squamous cell carcinoma with intralesional methotrexate. J Am Acad Dermatol 2022;24:68-70. DOI: https://doi.org/10.1016/j.jdcr.2022.04.016
Bergón-Sendín M, Pulido-Pérez A, Rosell-Díaz AM, et al. Neoadjuvant intralesional methotrexate in small-sized cutaneous squamous cell carcinoma: a prospective study in 84 patients. Aust J Dermatol 2020;62:e308-e310. DOI: https://doi.org/10.1111/ajd.13520
Bergón-Sendín M, Parra-Blanco V, Pulido-Pérez A, et al. Histological findings after intralesional methotrexate treatment in cutaneous squamous cell carcinoma. Dermatol Ther 2020;33:e14377. DOI: https://doi.org/10.1111/dth.14377
Salido-Vallejo R, Cuevas-Asencio I, Garnacho-Sucedo G, et al. Neoadjuvant intralesional methotrexate in cutaneous squamous
cell carcinoma: a comparative cohort study. J Eur Acad Dermatol Venereol 2015;30:1120-4. DOI: https://doi.org/10.1111/jdv.13266
How to Cite
A case of grade 3 squamous cell carcinoma successfully treated with methotrexate. (2024). Dermatology Reports, 16(1). https://doi.org/10.4081/dr.2024.9647
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