Case Reports
17 October 2023
Vol. 16 No. 2 (2024)
https://doi.org/10.4081/dr.2023.9771

Hydroxychloroquine-induced generalized myopathy in a patient with lupus tumidus: a case report

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Cutaneous lupus erythematosus, lupus tumidus, hydroxychloroquine-induced myopathy, drug reaction, tacrolimus ointment
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Authors

Alice Verdelli
alice.verdelli@hotmail.it
Rare Dermatological Diseases Unit, Department of Health Sciences, Toscana Centro Local Health Unit, Florence; European Reference Network Skin Member, Italy.
Daniela Massi
Section of Pathology, Department of Health Sciences, University of Florence, Italy.
Vincenza Maio
Section of Pathology, Department of Health Sciences, University of Florence, Italy.
Gabriele Cavazza
https://orcid.org/0009-0007-9373-0705
Section of Dermatology, Department of Health Sciences, University of Florence, Italy.
Alberto Corrà
https://orcid.org/0000-0003-0903-4998
1Rare Dermatological Diseases Unit, Department of Health Sciences, Toscana Centro Local Health Unit, Florence; European Reference Network Skin Member, Italy.
Elena Biancamaria Mariotti
Section of Dermatology, Department of Health Sciences, University of Florence, Italy.
Lavinia Quintarelli
https://orcid.org/0000-0002-9228-8042
Rare Dermatological Diseases Unit, Department of Health Sciences, Toscana Centro Local Health Unit, Florence; European Reference Network Skin Member, Italy.
Valentina Ruffo Di Calabria
https://orcid.org/0000-0003-0307-6636
Section of Dermatology, Department of Health Sciences, University of Florence, Italy.
Cristina Aimo
Section of Dermatology, Department of Health Sciences, University of Florence, Italy.
Emiliano Antiga
https://orcid.org/0000-0001-7787-4433
Section of Dermatology, Department of Health Sciences, University of Florence, Italy.
Marzia Caproni
https://orcid.org/0000-0002-7471-3471
Rare Dermatological Diseases Unit, Department of Health Sciences, Toscana Centro Local Health Unit, Florence; European Reference Network Skin Member; Section of Dermatology, Department of Health Sciences, University of Florence, Italy.

A subtype of cutaneous lupus erythematosus known as lupus erythematosus tumidus (LET) is characterized by sun-exposed areas that typically display urticaria-like papules and plaques. For LET, systemic therapy with antimalarials – particularly hydroxychloroquine (HCQ) – is the first line of treatment. Even though the safety profile of these medications appears to be high, there have been very few reports of side effects in the literature, including hemolytic anemia, retinal toxicity, maculopapular rash, gastrointestinal disturbance, and blue-gray discoloration of the skin or mucous membranes. Here, we report a unique instance of a 46- year-old LET smoker who, following HCQ treatment, developed a generalized myopathy.

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Hydroxychloroquine-induced generalized myopathy in a patient with lupus tumidus: a case report. (2023). Dermatology Reports, 16(2). https://doi.org/10.4081/dr.2023.9771
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