Articles
8 June 2009
Vol. 2 No. 3: Cervo Preclinical Working Conference, Cervo Ligure, October 6-8, 2005
https://doi.org/10.4081/hmr.v2i3.360

Modulation of dendritic cell function by zoledronate

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V Kunzmann
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Dendritic cells (DC) as professional antigen presenting cells (APC) play a central role in initiating an effective immune response. However, activation and maturation of DCs is critical for induction of an immune response. Activated innate lymphocytes (NK cells, NKT cells or gd T cells) have been shown to mediate the most potent activation/maturation signals to DCs by cytokines (TNF-α, IFNγg) and by cell-cell contact dependent signals (e.g. CD40-C40L interaction).

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Modulation of dendritic cell function by zoledronate. (2009). Hematology Meeting Reports (formerly Haematologica Reports), 2(3). https://doi.org/10.4081/hmr.v2i3.360