Cutaneous T-cell lymphomas: histology

Non-Hodgkin’s lymphomas are a heterogeneous group of tumors that arise from the lymphoreticular system. Approximately one third of non-Hodgkin’s lymphomas occur in extranodal sites, and the skin is the second most common site of extranodal in volvement after the gastrointestinal tract. Primary cutaneous lymphomas often have a different clinical behaviour and prognosis from histologically similar systemic lymphomas involving the skin secondarily, and therefore require different types of therapies.