Animal models of T-cell lymphomas

Y-W Lin; PD Aplan

doi:10.4081/hmr.v2i13.497

Abstracts

10 June 2009

Vol. 2 No. 13 (2006)

https://doi.org/10.4081/hmr.v2i13.497

Animal models of T-cell lymphomas

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Y-W Lin

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PD Aplan

We firmly believe that a better understanding of the molecular mechanisms that cause malignant transformation will lead to more effective therapies for patients with hematologic malignancy. Most hematologic malignancies have been shown to bear chromosomal aberrations such as translocations, deletions, and duplications. Therefore, we have investigated whether those genetic alterations were crucial for malignant transformation using animal, especially mouse, models.