Articles
16 June 2009
Vol. 2 No. 15: Secondary Leukemias and leukemogenesis Rome, 3-4 November 2006
https://doi.org/10.4081/hmr.v2i15.610

Therapy-related leukemia: clinical characteristics and analysis of new molecular risk factors in 114 adult patients

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Authors

D Rund
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S Krichevsky
S Bar-Cohen
N Goldschmidt
M Kedmi
E Malik
A Gural
S Shafran-Tikva
S Ben-Neriah
D Ben-Yehuda
We studied the clinical characteristics of 114 patients with therapy-related leukemia or therapy related myelodysplastic syndrome (t-Leuk/MDS). The mean age of the patients was 48 years. The Hematological malignancies were the most common primary (53%), followed by breast and ovarian cancer (30% combined). The mean latency until the development of t-Leuk/MDS was 45.5 months. Median survival was 10 months. Cytogenetics was abnormal in 89% of the patients. FLT3 internal tandem duplications were found in six of 41 (14.6%) patients, of whom four had an abnormal karyotype

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Therapy-related leukemia: clinical characteristics and analysis of new molecular risk factors in 114 adult patients. (2009). Hematology Meeting Reports (formerly Haematologica Reports), 2(15). https://doi.org/10.4081/hmr.v2i15.610