Articles
16 June 2009
Vol. 2 No. 15: Secondary Leukemias and leukemogenesis Rome, 3-4 November 2006
https://doi.org/10.4081/hmr.v2i15.612

Epigenetic targets for treatment in acute myeloid leukemia

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Authors

Giuseppe Cimino
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Francesco Lo Coco
Clara Nervi
Myelopoiesis, which involves growth and maturation of granulocytic and monocytic lineages, is highly controlled by lineage-specific hematopoietic transcription factors such as AML1, PU-1, C/EBPa, CBFb, retinoic acid receptor a (RARa) etc. that cooperatively interact with specific DNA sequences and directly activate or repress the expression of myeloid specific genes.

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Epigenetic targets for treatment in acute myeloid leukemia. (2009). Hematology Meeting Reports (formerly Haematologica Reports), 2(15). https://doi.org/10.4081/hmr.v2i15.612