microRNAs and cancer
13 December 2010
Featured Articles
https://doi.org/10.4081/jnai.2130

MicroRNAs as biomarkers for the diagnosis and prognosis of human cancer

Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Micro RNA, Cancer, Biomarker, Chronic Lymphocytic Leukemia
7272
Views
640
Downloads
3280
HTML

Authors

Daniela Asslaber
a.egle@salk.at
Laboratory for Immunological and Molecular Cancer Research, University Hospital, Salzburg, Austria.
Josefina Piñón Hofbauer
Richard Greil
Alexander Egle
miRNAs are small-noncoding RNA molecules that regulate gene expression on a posttranscriptional level. A number of oncogenes and tumor suppressors were found to be targets of miRNAs and global miRNA expression signatures were able to distinguish between cancerous and non-cancerous tissues. Therefore it was not surprising that some miRNAs could be linked to the pathogenesis of cancer. In this review we provide an overview of the use of microRNAs as diagnostic and prognostic tools in cancer and focus on the use of miRNA expression as biomarker for disease activity.

Altmetrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC

Supporting Agencies

This work was supported by Austrian FWF grants P19481 and L488 to A.E., Austrian National Bank grant 10990 to A.E., and by the state of Salzburg and the SFB 021 to R.G.
Daniela Asslaber, Laboratory for Immunological and Molecular Cancer Research, University Hospital, Salzburg
not applicable

How to Cite



MicroRNAs as biomarkers for the diagnosis and prognosis of human cancer. (2010). Journal of Nucleic Acids Investigation. https://doi.org/10.4081/jnai.2130
Copyright (c) 2010 Daniela Asslaber, Josefina Piñón Hofbauer, Richard Greil, Alexander Egle Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.