First case report of Stevens-Johnson syndrome complicated with macrophage activation syndrome

Stevens-Johnson syndrome (SJS) is a complex immunological syndrome with high morbidity and mortality and characterized by acute blistering affecting the skin and at least two mucous membranes. Macrophage activation syndrome (MAS) is a severe, potentially life-threatening syndrome that often occurs in children and adults with autoimmune disease, especially systemic-onset juvenile idiopathic arthritis or adult-onset Still’s disease. This case report highlights the potential risks of SJS developing into MAS, and suggests that rapid diagnosis and treatment are essential to achieving favorable outcomes.