Articoli originali
18 gennaio 2024
V. 11 (2023)
SARS-CoV-2 vs Streptococcus pneumoniae: confronto di caratteristiche cliniche, risultati di laboratorio ed outcome clinici in pazienti ricoverati presso l’Ospedale di Alessandria
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Obiettivi: lo scopo del presente studio è stato quello di confrontare le caratteristiche cliniche, anamnestiche, di laboratorio e gli outcome della polmonite da SARS-CoV-2 e la polmonite causata da Streptococcus pneumoniae in pazienti ricoverati presso l’Ospedale di Alessandria. Metodi: diagnosi radiologica di polmonite mediante radiografia del torace e/o Tomografia Computerizzata (TC) del torace; diagnosi microbiologica dell’infezione da SARS-CoV-2 mediante tampone rinofaringeo RT-2PCR, diagnosi eziologica della polmonite di S. pneumoniae mediante individuazione positiva dell’antigene urinario e/o isolamento di S. pneumoniae da colture respiratorie e/o ematiche. Risultati: 222 pazienti inclusi, 171 con polmonite da SARS-CoV-2 e 51 con polmonite da S. pneumoniae. Gruppo SARS-CoV-2 più frequentemente trattato con farmaci antivirali: 139/171 (81,3%) vs 1/51 (2,1%); p<0,001; hanno spesso bisogno di ossigenoterapia: 142/171 (83%) vs 27/51 (56,3%); p<0,001; e ventilazione meccanica non invasiva: 59/171 (34,5%) vs 7/51 (14,6%); p=0.004. La mortalità è stata più alta nei pazienti con polmonite SARS-CoV-2: 46/171 (26,9%) rispetto ai pazienti con polmonite pneumococcica 5/51 (9,8%); p=0,011. Conclusioni: lo studio ha mostrato una maggiore prevalenza di polmonite causata da SARS-CoV-2 e S. pneumoniae nei maschi piuttosto che nelle femmine. Inoltre, i pazienti con polmonite SARS-CoV-2 rappresentano un gruppo a rischio più elevato di complicanze e morte rispetto a S. pneumoniae.
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SARS-CoV-2 vs Streptococcus pneumoniae: confronto di caratteristiche cliniche, risultati di laboratorio ed outcome clinici in pazienti ricoverati presso l’Ospedale di Alessandria. (2024). Working Paper of Public Health, 11(1). https://doi.org/10.4081/wpph.2023.9809
Copyright (c) 2024 Iacopo Megna, Serena Penpa, Antonella Cassinari, Christian Leli, Andrea Rocchetti, Annalisa Roveta, Marta Betti, Antonio Maconi
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