Original Article(s)
30 November 2022
Vol. 10 (2022)
Monitoring of toxicity complications in patients undergoing CAR-T: observational, prospective study
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Background: CAR-T therapies are still a new field and toxicity management is in its early stages; targeted research addressing critical issues related to patient outcomes is therefore needed. The study aims to monitor the incidence of toxicity complications due to CAR-T during the period related to hospitalization. Methods: Observational, prospective, monocentric study. The sample will consist of all patients aged ≥18 years who are candidates for treatment with CAR-T from April 2022 to April 2025. The following rating scales will be used for data collection: Numeric Rating Scale for Pain, Adverse Events Sheet, Immune Effector Cell-associated Encephalopathy Score, Grading WHO, EuroQol-5D-3L, Hospital Anxiety Scale, Scored Patient-Generated Subjective Global Assessment, Contentment with Life Assessment Scale. Conclusions: Immunotherapy and CAR-T have shown promise in treating some malignancies. Still, they may be associated with different and not fully understood toxicities that can be fatal if not identified early and treated appropriately. Understanding complications could improve patient outcomes.
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Monitoring of toxicity complications in patients undergoing CAR-T: observational, prospective study. (2022). Working Paper of Public Health, 10(1). https://doi.org/10.4081/wpph.2022.9543
Copyright (c) 2022 Francesca Palmisano, Roberta Di Matteo, Chiara Cannici, Martina Milioto, Martina Riccomagno, Rosanna Gaino, Ignazio Favata, Paolo Rivela, Simona Arcidiacono, Lorella Gambarini, Tatiana Bolgeo, Antonio Maconi
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