Case report(s)
26 July 2023
Vol. 11 (2023)
https://doi.org/10.4081/wpph.2023.9665

A rare case of meningoencephalitis due to Aspergillus fumigatus

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cerebral aspergillosis, immunocompetent, Aspergillus, fungi
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Authors

Cesare Bolla
Infectious Diseases, Department of Internal Medicine, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Tommaso Lupia
https://orcid.org/0000-0002-3865-9519
Infectious Diseases Unit, Cardinal Massaia Hospital, Asti, Italy.
Andrea Schimmenti
Infectious Diseases, Department of Internal Medicine, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Alberto Gaviraghi
Department of Medical Sciences, University of Turin, Italy.
Serena Penpa
serena.penpa@ospedale.al.it
Infectious Diseases, Department of Internal Medicine, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Annalisa Roveta
https://orcid.org/0000-0003-2484-0963
Infectious Diseases, Department of Internal Medicine, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Francesco Giuseppe De Rosa
https://orcid.org/0000-0001-8338-0130
Infectious Diseases Unit, Cardinal Massaia Hospital, Asti; Department of Medical Sciences, University of Turin, Italy.
Guido Chichino
Infectious Diseases, Department of Internal Medicine, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Antonio Maconi
https://orcid.org/0000-0002-1904-7277
Infectious Diseases, Department of Internal Medicine, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.

Cerebral Aspergillosis (CA) is an opportunistic fungal infection that usually affects immunocompromised hosts. A man was admitted for loss of consciousness and aphasia. Computed Tomography (CT) scan showed a left cerebral frontal lesion. Nasal swab showed hyphae of Aspergillus spp.; isavuconazole was started. Lumbar Puncture (LP) tested positive for galactomannan (index 1.9), and Aspergillus fumigatus grew on the Cerebrospinal Fluid (CSF) culture. Unfortunately, a new episode of fever and a general deterioration then ensued up to the death. In immunocompetent patients as well, chronic fungal rhinosinusitis deserves attention due to its potential for rapid evolution to Central Nervous System (CNS) involvement.

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How to Cite



A rare case of meningoencephalitis due to Aspergillus fumigatus. (2023). Working Paper of Public Health, 11(1). https://doi.org/10.4081/wpph.2023.9665
Copyright (c) 2023 Cesare Bolla, Tommaso Lupia, Andrea Schimmenti, Alberto Gaviraghi, Serena Penpa, Annalisa Roveta, Francesco Giuseppe De Rosa, Guido Chichino, Antonio Maconi Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.