Original Article(s)
29 July 2022
Vol. 10 (2022)
https://doi.org/10.4081/wpph.2022.9507

Role of D-chiro-inositol in the management of gestational diabetes mellitus: impact on maternal and fetal outcomes

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pregnancy, insulin resistance, hyperglycaemia, supplements
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Authors

Selene Narcisi
Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale “Amedeo Avogadro”, Alessandria, Italy.
Stefano Allasia
SC Endocrinologia e Malattie Metaboliche, AO “SS. Antonio e Biagio e Cesare Arrigo”, Alessandria, Italy.
Marcella Balbo
SC Endocrinologia e Malattie Metaboliche, Azienda Sanitaria Locale “Città di Torino”, Turin, Italy.
Cristina Cappa
SC Endocrinologia e Malattie Metaboliche, AO “SS. Antonio e Biagio e Cesare Arrigo”, Alessandria, Italy.
Enrico Gabellieri
SC Endocrinologia e Malattie Metaboliche, AO “SS. Antonio e Biagio e Cesare Arrigo”, Alessandria, Italy.
Paola Leporati
SC Endocrinologia e Malattie Metaboliche, AO “SS. Antonio e Biagio e Cesare Arrigo”, Alessandria, Italy.
Barbara Lucatello
SC Endocrinologia e Malattie Metaboliche, AO “SS. Antonio e Biagio e Cesare Arrigo”, Alessandria, Italy.
Alberto Ragni
SC Endocrinologia e Malattie Metaboliche, AO “SS. Antonio e Biagio e Cesare Arrigo”, Alessandria, Italy.
Marco Gallo
marco.gallo@ospedale.al.it
SC Endocrinologia e Malattie Metaboliche, AO “SS. Antonio e Biagio e Cesare Arrigo”, Alessandria, Italy.

Introduction. D-chiro-inositol (DCI) mediates insulin action and demonstrated a positive effect on metabolic parameters when administered in pregnant women with gestational diabetes mellitus (GDM). The aim of this study was to evaluate the impact of DCI supplementation in GDM patients on metabolic control and maternal and fetal outcomes.

Patients and methods. A cohort comprising 20 women with GDM was retrospectively evaluated; all the women were treated with a standard diet and half of them was given DCI. Several parameters (glycaemic control, total daily insulin dose, maternal and fetal biometric parameters) have been evaluated in all subjects and compared between the two groups (DCI vs control group).

Results. Women within the DCI group showed a tendency to a lower total daily insulin dose, better postprandial glucose values and lower birth weight. Given the small sample size, differences between the two groups were not statistically significant. 

Conclusions. Supplementation with DCI in women with GDM is safe and, together with standard therapy, it seems to improve maternal metabolic parameters, in addition to exert a positive role in fetal development.

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Citations

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How to Cite



Role of D-chiro-inositol in the management of gestational diabetes mellitus: impact on maternal and fetal outcomes. (2022). Working Paper of Public Health, 10(1). https://doi.org/10.4081/wpph.2022.9507